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Advanced filters: Author: Adrien Delpal Clear advanced filters

  • The drug AT-527 targets the SARS-CoV-2 replication machinery. Here the authors use Cryo-EM to show how AT-527 inhibits SARS-CoV-2 polymerase by acting as an immediate RNA chain terminator and stably binding in a NiRAN active-site pocket; impeding an essential nucleotide-transfer activity.

    • Ashleigh Shannon
    • Véronique Fattorini
    • Bruno Canard
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9