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Showing 1–3 of 3 results
Advanced filters: Author: Adrien Favier Clear advanced filters

  • NMR structure determination is challenging for proteins with a molecular weight above 30 kDa and atomic-resolution structure determination from cryo-EM data is currently not the rule. Here the authors describe an integrated structure determination approach that simultaneously uses NMR and EM data and allows them to determine the structure of the 468 kDa dodecameric aminopeptidase TET2 complex.

    • Diego F. Gauto
    • Leandro F. Estrozi
    • Jerome Boisbouvier
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • To refold client proteins, HSP90 chaperone undergoes large structural rearrangements. Here the authors use NMR and molecular simulation and reveal structure and dynamics of a key functionally relevant metastable state of human HSP90α N-terminal domain.

    • Faustine Henot
    • Elisa Rioual
    • Jerome Boisbouvier
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • L-Cysteine-derived thiazolidines have now been shown to be artificial substrates of the radical SAM enzyme HydE, which converts them into S-adenosyl-L-cysteine. Carbon–sulfur bonds are formed in a concerted mechanism that involves the formation of a C-centred radical that concomitantly attacks the S atom of a thioether. This is the first example of a radical SAM enzyme that reacts directly on a sulfur atom instead of abstracting an H-atom.

    • Roman Rohac
    • Patricia Amara
    • Yvain Nicolet
    Research
    Nature Chemistry
    Volume: 8, P: 491-500