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Showing 1–2 of 2 results
Advanced filters: Author: Adrien Herledan Clear advanced filters

  • Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, the authors identify pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through allosteric inhibition of its primary RND transporter.

    • Coline Plé
    • Heng-Keat Tam
    • Ruben C. Hartkoorn
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Inhibiting insulin-degrading enzyme (IDE) has been proposed as a potential therapeutic strategy for the treatment of patients with diabetes. Here, the authors develop a novel IDE inhibitor but find that, surprisingly, IDE inhibition has negative effects on glucose tolerance in mice.

    • Rebecca Deprez-Poulain
    • Nathalie Hennuyer
    • Benoit Deprez
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13