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Showing 1–13 of 13 results
Advanced filters: Author: Adrienne Boire Clear advanced filters

  • In this Viewpoint article, we asked four experts to provide their opinions on important aspects of brain metastasis biology, focusing on the unique microenvironment and therapeutic targets in the brain, preclinical models and how studying brain metastases could inform primary brain tumour biology.

    • Adrienne Boire
    • Priscilla K. Brastianos
    • Manuel Valiente
    Reviews
    Nature Reviews Cancer
    Volume: 20, P: 4-11

  • In this Roadmap, Boire et al. consider the immediate causes of mortality in patients with cancer, a topic not often considered in either preclinical or clinical research, and provide recommendations for how we can stimulate research to advance our mechanistic understanding of these causes with a long-term view to improving the quality of life for patients with late-stage cancer.

    • Adrienne Boire
    • Katy Burke
    • Erik Sahai
    Reviews
    Nature Reviews Cancer
    Volume: 24, P: 578-589

  • A heterotypic cell interaction between astrocytes and tumour cells colonizing the brain is discovered; by establishing gap junctions, tumour cells trigger the activation of innate immune response signalling in astrocytes, which results in the secretion of factors that support growth and chemoresistance in brain metastatic cells.

    • Qing Chen
    • Adrienne Boire
    • Joan Massagué
    Research
    Nature
    Volume: 533, P: 493-498

  • Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomeninges.

    • Jan Remsik
    • Xinran Tong
    • Adrienne Boire
    ResearchOpen Access
    Nature
    Volume: 643, P: 1087-1096

  • Metastasis to the leptomeninges causes substantial neurological morbidity and mortality. Owing to the lack of mechanistic studies in this area, patients still face a bleak clinical prognosis. In this Review, Remsik and Boire provide a biology-focused overview of recent developments enabled by preclinical models and omics analyses and outline the need for further mechanistic research on leptomeningeal metastasis.

    • Jan Remsik
    • Adrienne Boire
    Reviews
    Nature Reviews Cancer
    Volume: 24, P: 448-460

  • Mutations in the sodium channel NALCN promote epithelial cell shedding and dissemination independent of oncogenic transformation. This observation suggests that metastasis may not uniformly represent the end stage of carcinogenesis but can occur before oncogenic transformation.

    • Ana Rita Nobre
    • Adrienne Boire
    News & Views
    Nature Genetics
    Volume: 54, P: 1774-1775

  • The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology.

    • Denis Schapiro
    • Clarence Yapp
    • Peter K. Sorger
    Comments & Opinion
    Nature Methods
    Volume: 19, P: 262-267