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Showing 1–3 of 3 results
Advanced filters: Author: Advaitha Madireddy Clear advanced filters

  • Loss-of-function mutations in EP300/KAT3B and CBP/KAT3A have been implicated in the pathogenesis of cancer. Here, the authors reveal that the EP300 protein has a role in mediating replication fork protection at sites of replication stalling and show that EP300-mutated cells recapitulate features of BRCA-deficient cancers.

    • Angelica Barreto-Galvez
    • Mrunmai Niljikar
    • Advaitha Madireddy
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • First responders to the World Trade Center disaster, who were exposed to particulate matter containing potential carcinogens, have a high burden of somatic mutations in blood cells, raising their risk for cancer and other diseases and highlighting the need for enhanced health screening of these individuals.

    • Sakshi Jasra
    • Orsi Giricz
    • Amit Verma
    Research
    Nature Medicine
    Volume: 28, P: 468-471

  • Tumor suppressor BRCA2 is known to stabilize and restart stalled DNA replication forks. Here the authors show that BRCA2 is recruited to the replication fork through its interaction with MCM10 and inhibits Primase-Polymerase-mediated repriming, lesion bypass and single strand DNA gap formation after DNA damage.

    • Zhihua Kang
    • Pan Fu
    • Bing Xia
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12