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Showing 1–3 of 3 results
Advanced filters: Author: Affaf Aliouat Clear advanced filters

  • This study uses somatic mutations as a natural barcoding system to retrospectively and prospectively trace the fate of hematopoietic stem cells across all major blood cell lineages in healthy aged individuals. It reveals the existence of intrinsically fate-biased hematopoietic stem cells in native human hematopoiesis, validated by transplantation assays.

    • Tetsuichi Yoshizato
    • Christer Nilsson
    • Sten Eirik W. Jacobsen
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 3088-3100

  • Jacobsen and colleagues elucidate the nonhierarchical relationship between two types of stem cells: Vwf− hematopoietic stem cells that stably replenish all blood cell lineages without a platelet bias, and Vwf+ stem cells that replenish almost exclusively platelets, and demonstrate that the two types utilize cellularly and molecularly distinct progenitor trajectories for replenishment of platelets.

    • Joana Carrelha
    • Stefania Mazzi
    • Sten Eirik W. Jacobsen
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 1007-1019