Nature Search

Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals

Pietro Scaduto
Adolfo Sequeira
Agenor Limon
ResearchOpen Access25 May 2020
Scientific Reports

Volume: 10, P: 1-8
Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

Synaptic loss may disturb the excitatory to inhibitory balance (E/I ratio) in circuits vulnerable in Alzheimer’s disease (AD). The authors find reduced synaptic levels of PSD-95 and gephyrin and show that individuals with AD exhibit a pro-excitatory shift of postsynaptic densities and the electrophysiological synaptic E/I ratio in the parietal cortex.

Julie C. Lauterborn
Pietro Scaduto
Agenor Limon
ResearchOpen Access10 May 2021
Nature Communications

Volume: 12, P: 1-15
βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia

Jessica Di Re
Michela Marini
Fernanda Laezza
ResearchOpen Access07 Feb 2025
Molecular Psychiatry

Volume: 30, P: 3090-3102
Common mitochondrial deletions in RNA-Seq: evaluation of bulk, single-cell, and spatial transcriptomic datasets

A methods application study demonstrates that the Splice-Break2 pipeline can detect large mitochondrial DNA deletions in RNA-Seq data. Analyses includes GTEx and GEO datasets and demonstrate differences across tissues, brain regions, and age.

Audrey A. Omidsalar
Carmel G. McCullough
Brooke E. Hjelm
ResearchOpen Access17 Feb 2024
Communications Biology

Volume: 7, P: 1-20
Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia

Anton Schulmann
Stefano Marenco
Francis J. McMahon
ResearchOpen Access17 Mar 2023
Translational Psychiatry

Volume: 13, P: 1-8
Regional transcriptome analysis of AMPA and GABA_A receptor subunit expression generates E/I signatures of the human brain

Kevin Shen
Tommaso Zeppillo
Agenor Limon
ResearchOpen Access09 Jul 2020
Scientific Reports

Volume: 10, P: 1-14
Human brain transcriptome analysis finds region- and subject-specific expression signatures of GABA_AR subunits

Adolfo Sequeira et al. report an analysis of GABA receptor subunit expression from single-cell and global transcriptome data generated by the Allen Institute. They find that GABA receptor subunit expression is spatially organized according to neurodevelopmental origin and generate a reference from the control population for future studies.

Adolfo Sequeira
Kevin Shen
Agenor Limon
ResearchOpen Access01 May 2019
Communications Biology

Volume: 2, P: 1-14
Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABA_A receptors

A. Limon
E. Delbruck
A. Sequeira
ResearchOpen Access05 Sept 2019
Translational Psychiatry

Volume: 9, P: 1-9

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