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Showing 1–12 of 12 results
Advanced filters: Author: Agnès Lehuen Clear advanced filters

  • Type 1 diabetes has a multifactorial etiology. Lehuen and colleagues demonstrate that MAIT cells serve both positive roles and negative roles in type 1 diabetes by maintaining gut integrity and limiting pancreatic inflammation but also directly destroying β-cells.

    • Ophélie Rouxel
    • Jennifer Da silva
    • Agnès Lehuen
    Research
    Nature Immunology
    Volume: 18, P: 1321-1331

  • Severe COVID-19 is characterized by hyperinflammation, and there is a need for accurate predictive biomarkers of progression. Lehuen et al. demonstrate that patients with severe COVID-19 show a dramatic loss of MAIT cells, and those that do remain are in a highly activated state.

    • Héloïse Flament
    • Matthieu Rouland
    • Agnès Lehuen
    Research
    Nature Immunology
    Volume: 22, P: 322-335

  • Harnessing invariant natural killer T cells can boost various immune responses. Two studies now shed light on the direct interaction between those cells and B cells that induce strong primary B cell responses.

    • Agnès Lehuen
    • Nicolas Fazilleau
    News & Views
    Nature Immunology
    Volume: 13, P: 11-13

  • Colonization of the mucosal tissues by iNKT cells was thought to be linked to the first contact with the environment. New research demonstrates that this process is regulated by and dependent on embryonic macrophages.

    • Léo Bertrand
    • Amine Toubal
    • Agnès Lehuen
    News & Views
    Nature Immunology
    Volume: 22, P: 681-682

  • Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducing dysbiosis of the intestinal microbiota.

    • Amine Toubal
    • Badr Kiaf
    • Agnès Lehuen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20

  • The early events in the pathogenesis of type 1 diabetes remain incompletely understood. Julien Diana et al. now show that in response to physiological beta cell death, innate immune cells including neutrophils and B1-a cells are recruited early on to pancreatic islets. These cells promote interferon-α production by plasmacytoid dendritic cells in the pancreas, promoting autoreactive T cell responses and autoimmunity.

    • Julien Diana
    • Yannick Simoni
    • Agnès Lehuen
    Research
    Nature Medicine
    Volume: 19, P: 65-73

  • Hepatic fibrosis represents the liver response to chronic injury and can lead to cirrhosis. Here the authors show that mucosal-associated invariant T cells mediate chronic inflammation and fibrogenesis in the liver by inducing a proinflammatory phenotype in macrophages and myofibroblasts and proliferation of the latter.

    • Pushpa Hegde
    • Emmanuel Weiss
    • Sophie Lotersztajn
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Here, the authors describe the complex interactions between cells of the innate immune system, the implications of these interactions for activation of adaptive immune cells and pancreatic β-cell death and the impact of infectious agents on these processes.

    • Agnès Lehuen
    • Julien Diana
    • Anne Cooke
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 501-513

  • Mucosal-associated invariant T cells display innate, effector-like qualities and are involved, in various ways, in infectious and non-infectious diseases. Insights into their activation, tissue migration and function are revealing their beneficial and deleterious roles in disease.

    • Amine Toubal
    • Isabelle Nel
    • Agnès Lehuen
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 643-657