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Showing 1–3 of 3 results
Advanced filters: Author: Agnes Klochendler Clear advanced filters

  • We describe a human DNA methylome atlas based on deep whole-genome bisulfite sequencing, allowing fragment-level analysis of cell-type-specific markers and providing an essential resource for studies of gene regulation and for deconvolution of cell mixtures and liquid biopsies.

    • Netanel Loyfer
    • Judith Magenheim
    • Tommy Kaplan
    ResearchOpen Access
    Nature
    Volume: 613, P: 355-364

  • Circulating cell-free DNA (cfDNA) has diagnostic potential, and clarifying its origins will aid in the minimally-invasive detection and monitoring of disease. Here, authors find that physiologically, megakaryocytes are major sources of cfDNA, while erythroblasts also release small amounts of cfDNA.

    • Joshua Moss
    • Roni Ben-Ami
    • Yuval Dor
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • As beta cells age their levels of p16 rise, and the cells become senescent; rather than leading to dysfunction, this results in an increased capacity of the beta cells for glucose-stimulated insulin secretion.

    • Aharon Helman
    • Agnes Klochendler
    • Ittai Ben-Porath
    Research
    Nature Medicine
    Volume: 22, P: 412-420