Nature Search

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease

The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.

Kevin Huynh
Wei Ling Florence Lim
Peter J. Meikle
ResearchOpen Access10 Nov 2020
Nature Communications

Volume: 11, P: 1-11
Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Stroke risk is influenced by genetic and lifestyle factors and previously a genomic risk score (GRS) for stroke was proposed, albeit with limited predictive power. Here, Abraham et al. develop a metaGRS that is composed of several stroke-related GRSs and demonstrate improved predictive power compared with individual GRS or classic risk factors.

Gad Abraham
Rainer Malik
Martin Dichgans
ResearchOpen Access20 Dec 2019
Nature Communications

Volume: 10, P: 1-10
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk

Some immune-mediated diseases may originate in early childhood. The authors mapped eQTLs and response eQTLs to various stimuli in neonatal myeloid cells and T cells, and revealed their potential role in immune-mediated diseases using colocalisation and Mendelian randomisation.

Qin Qin Huang
Howard H. F. Tang
Michael Inouye
ResearchOpen Access28 Jul 2020
Nature Communications

Volume: 11, P: 1-12
Author Correction: Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Gad Abraham
Rainer Malik
Martin Dichgans
Amendments and CorrectionsOpen Access20 Feb 2020
Nature Communications

Volume: 11, P: 1
Publisher Correction: Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Peter Savas
Balaji Virassamy
Sherene Loi
Amendments and Corrections22 Aug 2018
Nature Medicine

Volume: 24, P: 1941
Accessory subunits are integral for assembly and function of human mitochondrial complex I

Gene-editing technology and large-scale proteomics are used to provide insights into the modular assembly of the human mitochondrial respiratory chain complex I, as well as identifying new assembly factors.

David A. Stroud
Elliot E. Surgenor
Michael T. Ryan
Research14 Sept 2016
Nature

Volume: 538, P: 123-126
Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Extensive, high-dimensional characterization of T cells in breast cancer reveals activated T_RM population and a gene signature associated with improved prognosis.

Peter Savas
Balaji Virassamy
Sherene Loi
Research25 Jun 2018
Nature Medicine

Volume: 24, P: 986-993
Assessing and removing the effect of unwanted technical variations in microbiome data

Muhamad Fachrul
Guillaume Méric
Agus Salim
ResearchOpen Access23 Dec 2022
Scientific Reports

Volume: 12, P: 1-15
Clinicopathological significance of calreticulin in breast invasive ductal carcinoma

Zin-Mar Lwin
Chunhua Guo
Boon-Huat Bay
Research10 Sept 2010
Modern Pathology

Volume: 23, P: 1559-1566
Erratum: Regions of homozygosity in three Southeast Asian populations

Shu-Mei Teo
Chee-Seng Ku
Yudi Pawitan
Amendments and Corrections25 Jun 2012
Journal of Human Genetics

Volume: 57, P: 400
Direct inference and control of genetic population structure from RNA sequencing data

RGStraP is a computational pipeline to estimate RNA-seq-based genetic principal components and assess whether these can be used to control for population structure in gene expression analyses.

Muhamad Fachrul
Abhilasha Karkey
Michael Inouye
ResearchOpen Access02 Aug 2023
Communications Biology

Volume: 6, P: 1-9
Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization

Protein signatures of unstable and stable atherosclerosis are defined by quantitative proteomics using a preclinical mouse model of plaque instability/rupture.

Yung-Chih Chen
Meaghan Smith
Karlheinz Peter
ResearchOpen Access13 Mar 2023
Communications Biology

Volume: 6, P: 1-11
Optimization of OPEFB lignocellulose transformation process through ionic liquid [TEA][HSO₄] based pretreatment

Muhammad Nurdin
Haznan Abimanyu
Faizal Mustapa
ResearchOpen Access31 May 2021
Scientific Reports

Volume: 11, P: 1-11
Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes

Oyunchimeg Buyadaa
Agus Salim
Jonathan E. Shaw
ResearchOpen Access19 Jul 2021
Scientific Reports

Volume: 11, P: 1-8
Copy number polymorphisms in new HapMap III and Singapore populations

Chee-Seng Ku
Shu-Mei Teo
Agus Salim
Research16 Jun 2011
Journal of Human Genetics

Volume: 56, P: 552-560
A population-based study of copy number variants and regions of homozygosity in healthy Swedish individuals

Shu-Mei Teo
Chee-Seng Ku
Yudi Pawitan
Research02 Jun 2011
Journal of Human Genetics

Volume: 56, P: 524-533
Regions of homozygosity in three Southeast Asian populations

Shu-Mei Teo
Chee-Seng Ku
Yudi Pawitan
Research01 Dec 2011
Journal of Human Genetics

Volume: 57, P: 101-108
The discovery of human genetic variations and their use as disease markers: past, present and future

Chee Seng Ku
En Yun Loy
Kee Seng Chia
Reviews20 May 2010
Journal of Human Genetics

Volume: 55, P: 403-415

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