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TET3 regulates terminal cell differentiation at the metabolic level

TET3 is essential to postnatal development due to unknown reasons. Here Mulet et al. demonstrate that TET3 is required for ATP synthase assembly in differentiated cells and that its loss leads to an unphysiological metabolic profile.

Isabel Mulet
Carmen Grueso-Cortina
Natalia Tapia
ResearchOpen Access18 Nov 2024
Nature Communications

Volume: 15, P: 1-17
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

Mariana G. López
Álvaro Chiner-Oms
Iñaki Comas
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1405-1414
γ-Linolenic acid in maternal milk drives cardiac metabolic maturation

The switch from glucose- to fatty acid-dependent metabolism in cardiomyocytes of newborn mice is governed by γ-linolenic acid in maternal milk, which binds to retinoid X receptors, thereby causing a transcription-dependent metabolic transition.

Ana Paredes
Raquel Justo-Méndez
Mercedes Ricote
Research24 May 2023
Nature

Volume: 618, P: 365-373
Author Correction: γ-Linolenic acid in maternal milk drives cardiac metabolic maturation

Ana Paredes
Raquel Justo-Méndez
Mercedes Ricote
Amendments and Corrections15 Jun 2023
Nature

Volume: 619, P: E24
Safety and immunogenicity of a SARS-CoV-2 Gamma variant RBD-based protein adjuvanted vaccine used as booster in healthy adults

Here the authors show in a phase 1 trial that a recombinant subunit vaccine based on the gamma variant of SARS-CoV-2 exhibits a satisfactory safety profile, and induces a broad booster response of neutralizing antibodies and a booster effect on T cell immunity in individuals previously immunized with different SARS-CoV-2 vaccine platforms.

Karina A. Pasquevich
Lorena M. Coria
Juliana Cassataro
ResearchOpen Access28 Jul 2023
Nature Communications

Volume: 14, P: 1-12
Gut microbiota variations over the lifespan and longevity in rabbit’s maternal lines

Iliyass Biada
Maria A. Santacreu
Noelia Ibáñez-Escriche
ResearchOpen Access22 May 2025
Scientific Reports

Volume: 15, P: 1-12
Plasma metabolomic profiling in two rabbit lines divergently selected for intramuscular fat content

Comprehensive metabolomic profiling of plasma samples from two rabbit lines that were divergently selected for intramuscular fat content highlights the contribution of host genetics and microbial-derived metabolites to obesity or lipid deposition.

Agostina Zubiri-Gaitán
Agustín Blasco
Pilar Hernández
ResearchOpen Access31 Aug 2023
Communications Biology

Volume: 6, P: 1-10
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment

Martínez-Álvaro et al. employ metagenomic sequencing to compare the differences in caecum microbiome between lean and genetically obese rabbits exhibiting different levels of intramuscular fat. Lipid aggregation in muscle can be attributed to host genetic interactions with microbial biosynthetic products.

Marina Martínez-Álvaro
Agostina Zubiri-Gaitán
Agustín Blasco
ResearchOpen Access01 Nov 2021
Communications Biology

Volume: 4, P: 1-10
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

Luis Felipe Reyes
Alejandro Rodriguez
Neus Guasch
ResearchOpen Access21 Apr 2023
Scientific Reports

Volume: 13, P: 1-15
Small RNA-seq analysis of circulating miRNAs to identify phenotypic variability in Friedreich’s ataxia patients

Marta Seco-Cervera
Dayme González-Rodríguez
José Luis García-Giménez
ResearchOpen Access06 Mar 2018
Scientific Data

Volume: 5, P: 1-9

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