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Showing 1–6 of 6 results
Advanced filters: Author: Agustín Mangiarotti Clear advanced filters

  • Membrane-adsorbed condensates are crucial for biomolecular localization and can induce significant changes in membrane morphology, but the underlying mechanisms remain underexplored. Here, the authors combine imaging experiments and coarse-grained simulations to study poly-Lysine/poly-Aspartate (K10/D10) coacervates with different unilamellar liposomes, showing that their membrane affinity can be tuned by the anionic lipid content and quantified through the intrinsic contact angle both in vitro and in silico.

    • Sayantan Mondal
    • Agustín Mangiarotti
    • Qiang Cui
    ResearchOpen Access
    Communications Chemistry
    Volume: 9, P: 1-12

  • Membrane lipid packing, influenced by cholesterol, lipid chain length, and saturation, regulates the affinity of biomolecular condensates, enhancing their interactions with less ordered membranes and driving membrane remodeling, including nanotube and double-membrane sheet formation.

    • Agustín Mangiarotti
    • Elias Sabri
    • Rumiana Dimova
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Nano-environmental probes and advance imaging microscopy provide deep insight into protein phase separation and the interaction of condensates with membranes, revealing that wetting by condensates can modulate membrane lipid packing and hydration.

    • Agustín Mangiarotti
    • Macarena Siri
    • Rumiana Dimova
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Stress granules function at sites of intracellular membrane damage by forming on and stabilizing the ruptured membrane and promoting membrane repair.

    • Claudio Bussi
    • Agustín Mangiarotti
    • Maximiliano G. Gutierrez
    ResearchOpen Access
    Nature
    Volume: 623, P: 1062-1069

  • In this work, the authors investigated on the interaction of biomolecular condensates with membranes and report that they can exhibit two wetting transitions modulated by membrane or milieu composition. Condensate adhesion can trigger intriguing ruffling of the membrane interface into complex finger-like structures.

    • Agustín Mangiarotti
    • Nannan Chen
    • Rumiana Dimova
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15