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Showing 1–10 of 10 results
Advanced filters: Author: Ai Kaiho Clear advanced filters

  • Hyperosmotic stress leads to a phase separation of the proteasome, triggered by interactions between RAD23B and ubiquitylated proteins, which bring together p97 and proteasome-associated proteins into nuclear proteolytic foci.

    • Sayaka Yasuda
    • Hikaru Tsuchiya
    • Yasushi Saeki
    Research
    Nature
    Volume: 578, P: 296-300

  • Targeted protein degradation harnessing the ubiquitin system is a groundbreaking modality in drug discovery. Here, the authors identify cellular signaling pathways, such as PARG, PERK, or HSP90, that modulate the targeted degradation of the anticancer targets such as BRD4 induced by PROTACs.

    • Yuki Mori
    • Yoshino Akizuki
    • Fumiaki Ohtake
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • The 26S proteasome is assembled in several steps, however the extent to which this assembly occurs before or after transport into the nucleus remains unclear. Pack et al.show that full assembly can occur in the cytoplasm, and that a concatameric form of the fully assembled complex is a substrate for nuclear import.

    • Chan-Gi Pack
    • Haruka Yukii
    • Yasushi Saeki
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Akizuki et al. reveal an unexpected role for K63-linked ubiquitin chains and the E2 enzyme UBE2N in degrader-induced degradation of cIAP1 through the proteasome, demonstrating the diversity of the ubiquitin code used for targeted degradation.

    • Yoshino Akizuki
    • Mai Morita
    • Fumiaki Ohtake
    Research
    Nature Chemical Biology
    Volume: 19, P: 311-322

  • A study from the FANTOM consortium using single-molecule cDNA sequencing of transcription start sites and their usage in human and mouse primary cells, cell lines and tissues reveals insights into the specificity and diversity of transcription patterns across different mammalian cell types.

    • Alistair R. R. Forrest
    • Hideya Kawaji
    • Yoshihide Hayashizaki
    Research
    Nature
    Volume: 507, P: 462-470

  • The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differentiation process.

    • Harukazu Suzuki
    • Alistair R R Forrest
    • Yoshihide Hayashizaki
    Research
    Nature Genetics
    Volume: 41, P: 553-562

  • Ubiquitylation is a dynamic post-translational modification involved in the regulation of numerous cellular processes. Here the authors describe Ub-ProT: a method to measure the length of substrate-attached ubiquitin chains in biological samples, and demonstrate a critical role for chain length in directing substrates to specific cellular pathways.

    • Hikaru Tsuchiya
    • Daocharad Burana
    • Yasushi Saeki
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10