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Showing 1–3 of 3 results
Advanced filters: Author: Aifang Nie Clear advanced filters

  • Neurons in the dorsal motor nucleus of vagus are involved in the absorption of fat in the intestine, and the natural compound puerarin shows utility in modulating this brain–gut axis to reduce fat absorption.

    • Qianqian Lyu
    • Wenzhi Xue
    • Weiqing Wang
    Research
    Nature
    Volume: 634, P: 936-943

  • During the progression of type 2 diabetes, insulin-producing β-cells can lose their identity and become reprogrammed into other cell types. Here the authors show that murine diabetic β-cells require the protein Raptor for maintaining β-cell health and preventing them from turning into α-cells, independent of Raptor’s involvement in regulating blood sugar levels.

    • Qinglei Yin
    • Qicheng Ni
    • Guang Ning
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • mTORC1 regulates beta cell survival, function and adaptation to physiologic and pathological stimuli. Here Niet al. demonstrate that that deficiency of Raptor, a component of mTORC1 complex, impairs insulin secretion and glucose tolerance in mice by affecting maturation of beta cells during the postnatal period.

    • Qicheng Ni
    • Yanyun Gu
    • Qidi Wang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13