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Showing 1–4 of 4 results
Advanced filters: Author: Aihong Gu Clear advanced filters

  • The evolutionarily conserved complex, the Par proteins, regulates cell polarity. Here, the authors show that in Drosophila neuroblasts, the Par complex exhibits liquid–liquid phase separation dependent on the cell cycle.

    • Ziheng Liu
    • Ying Yang
    • Wenyu Wen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Wei et al. report that MBD2 forms condensates through phase separation in diverse cancers where it assembles the NuRD complex. MBD2 condensates are redox-sensitive and mediate transcriptional repression in cancer cells.

    • Heyang Wei
    • Hongdan Zheng
    • Wenyu Wen
    Research
    Nature Cell Biology
    Volume: 27, P: 801-816

  • HECT type E3 ligases are key regulators of cell growth and proliferation. Here the authors present the crystal structures of the Nedd4 family E3 ligase WWP1 in a closed and semi-open state and in combination with mutagenesis experiments identify a multi-lock regulatory mechanism that allows the fine-tuning of activities of Nedd4 family E3 ligases.

    • Zhen Wang
    • Ziheng Liu
    • Wenyu Wen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15