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Showing 1–5 of 5 results

Advanced filters: Author: Aijing Shan Clear advanced filters

Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes

The authors use Perturb-seq analysis in human pancreatic islet beta cells, as well as in vivo and in vitro analyses, to identify potential therapeutic targets for type 2 diabetes, including ZZEF1, which regulates insulin synthesis and cellular stress in islet β cells.

Jingminjie Nan
Xianglong He
Yanan Cao
Research02 Jan 2026
Nature Metabolism

Volume: 8, P: 139-158
Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1

Insulinomas develop from pancreatic β-cells and secrete insulin, but the underlying genetic defects are largely unknown. In this study, Cao et al. identify recurrent T372R mutations in the transcription factor YY1, and validate this hotspot mutation in 30% of insulinomas.

Yanan Cao
Zhibo Gao
Guang Ning
Research10 Dec 2013
Nature Communications

Volume: 4, P: 1-6
Mettl3 deficiency leads to impaired insulin secretion via regulating Ire1a of mature β-cells in mice

Xu Zhang
Aijing Shan
Xiuli Jiang
ResearchOpen Access29 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types

Yanan Cao
Weiwei Zhou
Guang Ning
Correspondence05 Mar 2018
Cell Research

Volume: 28, P: 601-604
The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals

Yanan Cao
Lin Li
Mengyao Wang
ResearchOpen Access30 Apr 2020
Cell Research

Volume: 30, P: 717-731