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Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

Vaccine efficiency is enhanced by mesoporous silica rods that spontaneously form a 3D microenvironment for immune cells.

Jaeyun Kim
Weiwei Aileen Li
David J Mooney
Research08 Dec 2014
Nature Biotechnology

Volume: 33, P: 64-72
Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

The immunosuppressive tumour microenvironment impairs immunotherapy in poorly immunogenic cancer. Here, the authors load an alginate gel with GM-CSF, CpG oligonucleotides and doxorubicin-iRGD to promote immunogenic death of tumour cells and improve immunotherapy efficacy in triple negative breast cancer models.

Hua Wang
Alexander J. Najibi
David J. Mooney
ResearchOpen Access10 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents inin vivoapplications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models.

Nandhini Ponnuswamy
Maartje M. C. Bastings
William M. Shih
ResearchOpen Access31 May 2017
Nature Communications

Volume: 8, P: 1-9
Metabolic labeling and targeted modulation of dendritic cells

Dendritic cells concentrated in vivo within a hydrogel have been metabolically tagged with azido groups to enable tracking as well as delivery of antigens, adjuvants and cytokines, thereby facilitating targeted immunomodulation.

Hua Wang
Miguel C. Sobral
David J. Mooney
Research18 May 2020
Nature Materials

Volume: 19, P: 1244-1252
A facile approach to enhance antigen response for personalized cancer vaccination

A strategy to enhance antigen immunogenicity is shown using polyethyleneimine adsorbed on mesoporous silica microrod vaccine as a platform for neoantigens, supporting potent humoral immune response and inhibition of tumour growth following vaccination.

Aileen Weiwei Li
Miguel C. Sobral
David J. Mooney
Research05 Mar 2018
Nature Materials

Volume: 17, P: 528-534

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Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

Metabolic labeling and targeted modulation of dendritic cells

A facile approach to enhance antigen response for personalized cancer vaccination

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