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Showing 1–9 of 9 results
Advanced filters: Author: Ailey K. Crow Clear advanced filters

  • A new MAP4K4–moesin–talin–β1-integrin pathway regulating endothelial cell motility was discovered through chemical and siRNA screens; loss of Map4k4 or inhibition of MAP4K4 kinase activity altered the sprout morphology of endothelial cells during angiogenesis by blocking moesin phosphorylation, which regulates the disassembly of focal adhesions, demonstrating that this pathway is involved in both normal and pathological angiogenesis.

    • Philip Vitorino
    • Stacey Yeung
    • Weilan Ye
    Research
    Nature
    Volume: 519, P: 425-430

  • Direct elevation of heart rate using noninvasive optogenetics in mice influences anxiety-like behaviours in specific environmental contexts, and the posterior insular cortex is implicated in this integration of signals from the heart with environmental risk information.

    • Brian Hsueh
    • Ritchie Chen
    • Karl Deisseroth
    ResearchOpen Access
    Nature
    Volume: 615, P: 292-299

  • The authors show that choice information is relayed from the ventrolateral orbitofrontal cortex to the dorsomedial striatum to lead accurate economic decision-making.

    • Felicity Gore
    • Melissa Hernandez
    • Karl Deisseroth
    ResearchOpen Access
    Nature Neuroscience
    Volume: 26, P: 1566-1574

  • Blood platelets aggregate to form clots that prevent haemorrhage. Knowledge of single-platelet mechanics is scarce, however. Atomic force microscopy experiments now show that platelets contract rapidly on contact with fibrinogen, and adhere strongly to multiple fibrin polymers, enhancing the elasticity of clots. These findings are relevant to disorders of platelet function, such as thrombosis.

    • Wilbur A. Lam
    • Ovijit Chaudhuri
    • Daniel A. Fletcher
    Research
    Nature Materials
    Volume: 10, P: 61-66

  • Surface two-photon imaging of the brain cannot access somatic calcium signals of neurons from deep layers of the macaque cortex. Here, the authors present an implant and imaging system for chronic motion-stabilized two-photon imaging of dendritic calcium signals to drive an optical brain-computer interface in macaques.

    • Eric M. Trautmann
    • Daniel J. O’Shea
    • Krishna V. Shenoy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-20

  • Many approaches exist to process data from individual imaging modalities, but integrating them is challenging. The authors develop an automated resource that enables co-registered network- and tract-level analysis of macroscopic in-vivo imaging and microscopic imaging of cleared tissue.

    • Maged Goubran
    • Christoph Leuze
    • Michael Zeineh
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The hypothalamus is a brain region rich in functionally segregated neurons. Here Romanov and colleagues use single-cell RNA sequencing to distinguish 62 neuronal subtypes and define their neuropeptide and neurotransmitter makeup. They then show that onecut-3-containing dopamine neurons populate the periventricular area and are wired into the circadian circuitry.

    • Roman A Romanov
    • Amit Zeisel
    • Tibor Harkany
    Research
    Nature Neuroscience
    Volume: 20, P: 176-188