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Showing 1–9 of 9 results
Advanced filters: Author: Airlie J. McCoy Clear advanced filters

  • An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of predicted structures do not agree with experimentally resolved data. Therefore, care must be taken when using these predictions for informing structural hypotheses.

    • Thomas C. Terwilliger
    • Dorothee Liebschner
    • Paul D. Adams
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 110-116

  • A new computational approach that can be used to refine the three dimensional structural models of proteins is described. When used to refine models generated from nuclear magnetic resonance data, the method can improve the accuracy of the structures in terms of the backbone conformations and the placement of core side chains. In addition, the approach can be used to generate significantly better solutions to the X-ray crystallographic phase problem in molecular replacement trials.

    • Bin Qian
    • Srivatsan Raman
    • David Baker
    Research
    Nature
    Volume: 450, P: 259-264

  • During clathrin-mediated endocytosis, cargo proteins are recognized by clathrin adaptors. The clathrin adaptor AP2 recognizes two major classes of endocytic motifs, including an acidic dileucine motif. This study presents the crystal structure of AP2 in complex with the diceucine motif of a cargo protein, thereby revealing the mechanism of cargo–adaptor recognition.

    • Bernard T. Kelly
    • Airlie J. McCoy
    • David J. Owen
    Research
    Nature
    Volume: 456, P: 976-979

  • The crystal structure of a SNARE protein bound to a clathrin adaptor is reported, which reveals that there is highly specific interactions between two folded domains as opposed to the linear peptide motif or folded domains that have been described for other families of cargo proteins. This is the first example of a SNARE association with a clathrin adaptor and describes a novel mechanism by which cargo can be recruited into clathrin coated vesicles.

    • Sharon E. Miller
    • Brett M. Collins
    • David J. Owen
    Research
    Nature
    Volume: 450, P: 570-574