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Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues

Tissue clearing has revolutionised histology, but limited penetration of antibodies and stains into thick tissue segments is still a bottleneck. Here, the authors characterise optically cleared tissue as an electrolyte gel and apply this knowledge to stain the entirety of thick tissue samples.

Etsuo A. Susaki
Chika Shimizu
Hiroki R. Ueda
ResearchOpen Access27 Apr 2020
Nature Communications

Volume: 11, P: 1-22
BALB/c-Fcgr2b^−/−Pdcd1^−/− mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis

Yoshio Sugino
Nobuyuki Nishikawa
Osamu Ogawa
ResearchOpen Access19 Mar 2012
Scientific Reports

Volume: 2, P: 1-7
Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment

Risa Okada
Shin-ichiro Fujita
Satoru Takahashi
ResearchOpen Access28 Apr 2021
Scientific Reports

Volume: 11, P: 1-15
TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window

Akiyoshi Kunugi
Maiko Tanaka
Haruhide Kimura
Research12 Sept 2018
Neuropsychopharmacology

Volume: 44, P: 961-970
Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging

This protocol describes how to perform CUBIC (Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis), a simple and efficient method for organ clearing, imaging by light-sheet microscopy, and quantitative imaging analysis.

Etsuo A Susaki
Kazuki Tainaka
Hiroki R Ueda
Protocols08 Oct 2015
Nature Protocols

Volume: 10, P: 1709-1727

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Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues

BALB/c-Fcgr2b−/−Pdcd1−/− mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis

Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment

TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window

Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging

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BALB/c-Fcgr2b^−/−Pdcd1^−/− mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis