Search

High-energy particles can be used for precise fabrication of nanostructures by inducing cross-linking between structures. Here the authors use a single particle fabrication technique to assemble protein nanowires, giving structures with high aspect ratios retaining biological functions.

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Branched ubiquitin chains promote substrates degradation. Here, the authors describe an interplay between two ubiquitin ligases, K29-linkage-specific TRIP12 and K48-linkage specific UBR5, which assembles K29/K48 branched ubiquitin chains and facilitates degradation of deubiquitylation-protected substrates.

Hyperosmotic stress leads to a phase separation of the proteasome, triggered by interactions between RAD23B and ubiquitylated proteins, which bring together p97 and proteasome-associated proteins into nuclear proteolytic foci.

Though electret materials are attractive for realizing flexible mechanoelectrical devices, these materials are typically solid films. Here, the authors report stretchable ‘liquid-electret’ devices consisting solvent-free liquid porphyrins that show piezoelectric and electroacoustic functionality.

Nonvolatile luminescent liquids are solvent-free fluids with a range of flexible electronic applications. Here, the authors show that anthracenes enveloped in branched aliphatic compounds are stable emissive liquids, with emissive and thermoresponsive properties that may be tuned by addition of dopants.

Covalent organic frameworks can utilize π-stacking interactions for the formation of ordered, layered frameworks. Here, the authors report an ordered framework with tailored π-interactions resulting in periodic ordering in three dimensions, which leads to enhanced stability and electronic properties.

Akizuki et al. reveal an unexpected role for K63-linked ubiquitin chains and the E2 enzyme UBE2N in degrader-induced degradation of cIAP1 through the proteasome, demonstrating the diversity of the ubiquitin code used for targeted degradation.

Ubiquitylation of histone H3 (H3Ub2) by UHRF1 recruits DNMT1 to chromatin, which is essential for DNA methylation inheritance. Here, the authors provide evidence that there are two distinct mechanisms underlying replication timing-dependent recruitment of DNMT1 through PAF15Ub2 and H3Ub2, both of which are required for high fidelity DNA methylation inheritance.

Identification of SDD1 mRNA from Saccharomyces cerevisiae as an endogenous RQC substrate allows analysis of the mechanism underlying translational stalling and Hel2-dependent polyubiquitination of collided ribosomes to provide insight into ribosome dissociation.

Amphiphilic self-assembly usually involves molecules consisting of hydrophobic and hydrophilic segments. Now, this concept has been broadened to encompass the self-assembly of fully hydrophobic molecules that contain mutually immiscible alkyl and π-conjugated segments. Selective additives — n-alkanes or C₆₀ — direct their assembly into various ordered and optoelectronically functional structures.

Optically active through-space conjugated polymers were prepared from planar chiral pseudo-meta-disubstituted [2.2]paracyclophane. The corresponding optically active pseudo-meta-linked dimers were also prepared, and their optical and chiroptical properties were compared with those of the pseudo-para- and pseudo-ortho-linked dimers. Optically active pseudo-meta-linked dimers and polymers emitted intense circularly polarized luminescence with good anisotropy factors on the order of 10^–3. The electrical photoconductivities of the racemic pseudo-meta- and pseudo-para-linked polymers were also evaluated. A number of properties were explained by using time-dependent density functional theory calculations.

The amorphous regions of π-conjugated polymers typically show lower functionality than the crystalline regions with high π–π stacking order. Here, a benzodithiophene–thiazolothiazole copolymer shows a greater coplanar backbone structure when the π–π stacking order is absent compared to the crystalline state.

This article reviews an evaluation-oriented exploration of photo energy conversion systems including organic photovoltaics, perovskite solar cells, photocatalysts, and photodetectors. A time-resolved spectroscopy using a gigahertz electromagnetic wave enables rapid screening of potential optoelectronics of organic/inorganic semiconductors and fast finding of their optimal film processing conditions. This approach is further empowered by machine learning that provides a high-throughput virtual screening in the large molecular space. The author discusses a perspective on this evaluation (from fundamental to application) and its effective combination with data science.

Performance limiting factors in three end-group-brominated ITIC (β, γ, δ):PM6 bulk-heterojunction (BHJ) organic solar cells (OSCs) were investigated. The charge carrier dynamics (mobility and its relaxation) in these OSCs were evaluated by simultaneous time-of-flight (TOF)-time-resolved microwave conductivity (TRMC) measurement and photoinduced charge extraction by linearly increasing voltage (photo-CELIV) technique. The charge separation and recombination were found to be stronger power conversion efficiency-governing factors than mobilities and their balance, as suggested by regression analyses.