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Showing 1–3 of 3 results
Advanced filters: Author: Akiyoshi Uezu Clear advanced filters

  • A cell-surface fragment complementation strategy is used to identify the proteome at the junction of astrocytes and synapses in vivo, and shows that NRCAM expressed in astrocytes has a key role in regulating inhibitory synapse function.

    • Tetsuya Takano
    • John T. Wallace
    • Scott H. Soderling
    Research
    Nature
    Volume: 588, P: 296-302

  • The internal molecular mechanisms that underlie excitatory synaptogenesis remain poorly characterized. This study utilizes a chemogenetic approach, in vivo biotin identification (iBioID), to discover previously uncharacterized proteins at nascent synapses. CARMIL3 is identified as a cytoskeletal protein that facilitates spine maturation and AMPAR recruitment.

    • Erin F. Spence
    • Shataakshi Dube
    • Scott H. Soderling
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • This study identifies a mechanism linking loss of Arp2/3 to the progressive formation of shaft excitatory synaptic contacts. This leads to enhanced cortical excitation, striatal hyperdopaminergia and antipsychotic-responsive psychomotor agitation. This illustrates how diverse pathologies may converge downstream of spine actin disturbances to drive psychomotor behaviors.

    • Il Hwan Kim
    • Mark A Rossi
    • Scott H Soderling
    Research
    Nature Neuroscience
    Volume: 18, P: 883-891