In-silico based in vitro and in vivo validations identified a lead molecule that specifically targets: ApoE4 protein; inhibits ApoE4::CLEAR DNA binding; rescues thwarted lysosomal autophagy; and protects against Aβ aggregation.
- Meenakshisundaram Balasubramaniam
- Jagadeesh Narasimhappagari
- W. Sue T. Griffin
