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Advanced filters: Author: Akshay Jayachandran Clear advanced filters

Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1

Triplet repeat expansions drive several human disorders. Here, the authors define biochemically an expansion pathway promoted by MutLγ and MutSβ, and a protective pathway catalyzed by FAN1, POLD and RFC-PCNA.

Issam Senoussi
Valentina Mengoli
Petr Cejka
ResearchOpen Access27 Oct 2025
Nature Communications

Volume: 16, P: 1-16

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Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1

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