Squamous cell carcinomas (SCCs) show poor survival due to the presence of cancer stem cells (CSCs). Here, the authors delineate the molecular mechanism underlying SCC progression by identifying a crosstalk of epigenetic-signaling metabolism axis, which showed global hypermethylation activates non-canonical Wnt signaling, in turn activating glycolysis in skin and oral SCC.
- Darshan Mehta
- Akshay Paradkar
- Sanjeev K. Waghmare
