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Showing 1–9 of 9 results
Advanced filters: Author: Alain Carpentier Clear advanced filters

  • Prosthetic aortic valves are often required for patients with aortic stenosis. The optimal choice of valve in middle-aged patients is not clear and the available options all have drawbacks. Patient choice is the most important factor in deciding which valve to use, with biological valves increasingly favored over mechanical valves. The authors of this Review present the various prosthetic aortic valves currently in use and discuss the implications of prosthesis selection in this group of patients.

    • Joanna Chikwe
    • Farzan Filsoufi
    • Alain F. Carpentier
    Reviews
    Nature Reviews Cardiology
    Volume: 7, P: 711-719

  • Cardiac tissue engineering could be useful for replacement and/or repair of diseased or malformed cardiac tissue. The creation of functional, biocompatible contractile tissues, however, remains challenging. These investigators report a novel method of engineering a highly effective collagen-cell scaffold based on arginine–glycine–aspartic acid–serine peptides cross-linked to a clinically approved collagen matrix.

    • Olivier Schussler
    • Catherine Coirault
    • Yves Lecarpentier
    Research
    Nature Reviews Cardiology
    Volume: 6, P: 240-249

  • Mitral valve disease is a common cause of heart failure and death. In this Review from members of the Leducq Transatlantic Network, Levine and colleagues extensively summarize the molecular and cellular mechanisms underlying the dynamic changes that occur during progression of mitral valve disease, and indicate how improved understanding of the pathophysiology might lead to the discovery of novel therapeutic options.

    • Robert A. Levine
    • Albert A. Hagége
    • Magdi H. Yacoub
    Reviews
    Nature Reviews Cardiology
    Volume: 12, P: 689-710

  • Anaplastic oligodendrogliomas are rare and incurable primary brain tumours with few treatment options. Here Labrecheet al. perform whole-exome sequencing and identify recurring mutations in transcription factor TCF12, which are associated with aggressive tumours.

    • Karim Labreche
    • Iva Simeonova
    • Michel Wager
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • A systemic approach which considers all stakeholders and combines multiple policy instruments is necessary to reduce global reliance on chemicals in agriculture, according to a review of the agronomic and economic challenges and barriers to existing policies.

    • Thierry Brunelle
    • Raja Chakir
    • Fiona H. M. Tang
    ReviewsOpen Access
    Communications Earth & Environment
    Volume: 5, P: 1-9