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Showing 1–5 of 5 results
Advanced filters: Author: Alan Barkun Clear advanced filters
  • Nonvariceal upper gastrointestinal bleeding (UGIB) is a major cause of morbidity and mortality worldwide, and despite improvements in the management of patients with this condition, there have only been moderate improvements in mortality rates. This Review discusses the diagnosis of UGIB and describes the optimal management of patients with this condition, in accordance with the current consensus recommendations and contemporary literature. The authors examine endoscopy, management of bleeding and pharmacological therapy for patients with UGIB.

    • Marc Bardou
    • Dalila Benhaberou-Brun
    • Alan N. Barkun
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 9, P: 97-104
  • Stress-related mucosal bleeding (SRMD) is an important issue owing to its severity, and its management in critically ill patients is especially difficult. In this Review, the latest information on the epidemiology, risk factors and management of SRMD are outlined to help guide clinicians of the most appropriate treatment strategies for patients in intensive care units.

    • Marc Bardou
    • Jean-Pierre Quenot
    • Alan Barkun
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 12, P: 98-107
  • This article considers the case of a 73-year-old white man who presented with synchronous gastric carcinomas and a 20-year history of mixed polyposis. Genetic-testing and molecular-pathology analyses confirmed a diagnosis of Cowden's syndrome. The case explores the diagnostic challenges of differentiating between hamartomatous and adenomatous polyposis syndromes in patients with mixed polyposis, and emphasizes the need to characterize the risk of gastrointestinal cancer in patients with this syndrome.

    • Khalid Al-Thihli
    • Laura Palma
    • William D Foulkes
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 6, P: 184-189