While information conveyed to the primary visual cortex (V1) by top-down signals is thought to be required for visual perceptual learning, it remains unknown whether it is possible to modulate visual perceptual learning by manipulating top-down neuronal activity. Here the authors employ a mouse model of visual perceptual learning in a forced-choice visual discrimination task to demonstrate an essential role of the latero-medial secondary visual cortex, the prime source for top-down feedback projections reentering V1.
- Alan Consorti
- Gabriele Sansevero
- Alessandro Sale
