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Showing 1–19 of 19 results
Advanced filters: Author: Alan Jasanoff Clear advanced filters

  • The authors use fMRI in rats to show that covert sensory input influences the dynamics of resting state brain activity. This indicates a mechanism by which the environment shapes neural function even in the absence of explicit stimuli or tasks.

    • Sarah Bricault
    • Miranda Dawson
    • Alan Jasanoff
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Targeted manipulations of neural activity in the living brain remain a significant challenge. In this study the authors introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging

    • Sarah Bricault
    • Ali Barandov
    • Alan Jasanoff
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-6

  • Noninvasive detection of molecular targets in living subjects could provide valuable insights into healthy function and disease. Here, the authors develop vasoactive imaging probes which allow wide-field in vivo mapping of nanomolar-level molecular species in rat brain.

    • Robert Ohlendorf
    • Agata Wiśniowska
    • Alan Jasanoff
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Molecular and functional magnetic resonance imaging in the rat reveals distinct neuromodulatory effects of striatal dopamine that extend beyond peak release sites and activate remote neural populations necessary for performing motivated actions.

    • Nan Li
    • Alan Jasanoff
    Research
    Nature
    Volume: 580, P: 239-244

  • There are only few MRI-compatible calcium reporters and they are limited to measuring extracellular calcium levels. Here the authors develop and validate a cell-permeable, manganese-based paramagnetic MRI contrast agent that enables monitoring intracellular calcium signals in vivo in the rat brain.

    • Ali Barandov
    • Benjamin B. Bartelle
    • Alan Jasanoff
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Magnetic manipulation of biological systems requires the development of improved molecular handles. Here the authors isolate ferritin mutants with enhanced biomineralization from a yeast genetic screen and show their application to cell separation, multiscale imaging, and construction of sensors.

    • Yuri Matsumoto
    • Ritchie Chen
    • Alan Jasanoff
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • The vasculature produces strong endogenous contrast in magnetic resonance imaging (MRI). Here Desai et al. report genetically encoded imaging probes derived from the vasodilator, calcitonin gene-related peptide, which allows visualization of molecular events via haemodynamic changes in optical imaging or MRI.

    • Mitul Desai
    • Adrian L. Slusarczyk
    • Alan Jasanoff
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Magnetic resonance imaging of hemoglobin in the brain can detect blood flow associated with neural activity, but direct imaging of neurotransmitters would provide a more sensitive measure of neural signal processing. Shapiro et al. use directed evolution to generate a protein probe that enables magnetic resonance imaging of the neurotransmitter dopamine.

    • Mikhail G Shapiro
    • Gil G Westmeyer
    • Alan Jasanoff
    Research
    Nature Biotechnology
    Volume: 28, P: 264-270

  • Magneto-fluorescent nanoparticles hold promise for bioimaging applications, but synthesizing uniform particles with tunable sizes remains challenging. Chen et al. propose an approach for co-assembling magnetic particles with fluorescent quantum dots, leading to well-defined core-shell structures.

    • Ou Chen
    • Lars Riedemann
    • Moungi G. Bawendi
    Research
    Nature Communications
    Volume: 5, P: 1-8

  • The implementation of ethics review processes is an important first step for anticipating and mitigating the potential harms of AI research. Its long-term success, however, requires a coordinated community effort, to support experimentation with different ethics review processes, to study their effect, and to provide opportunities for diverse voices from the community to share insights and foster norms.

    • Madhulika Srikumar
    • Rebecca Finlay
    • Joelle Pineau
    Comments & Opinion
    Nature Machine Intelligence
    Volume: 4, P: 1061-1064

  • Artificial compartments have been expressed in prokaryotes and yeast, but similar capabilities have been missing for mammalian cell engineering. Here the authors use bacterial encapsulins to engineer genetically controlled multifunctional orthogonal compartments in mammalian cells.

    • Felix Sigmund
    • Christoph Massner
    • Gil G. Westmeyer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • This study introduces genetically encoded imaging probes that convert intracellular calcium signaling into hemodynamic fMRI responses. The authors show how the probes can be used to map information flow in reward-related brain circuitry in rats.

    • Souparno Ghosh
    • Nan Li
    • Alan Jasanoff
    Research
    Nature Neuroscience
    Volume: 25, P: 390-398

  • Protein-actuated clustering of magnetic nanoparticles enables MRI-based measurement of extracellular calcium ion dynamics in the living rodent brain.

    • Satoshi Okada
    • Benjamin B. Bartelle
    • Alan Jasanoff
    Research
    Nature Nanotechnology
    Volume: 13, P: 473-477