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In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles

Virus-like particles are engineered to edit human hematopoietic cells in vivo.

Vladimir V. Botchkarev Jr.
Sean Harrington
Luca Biasco
ResearchOpen Access05 Dec 2025
Nature Biotechnology

P: 1-13
High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries

Two large-scale resources for studying microRNA function are presented: one is a library of fluorescent sensors with a corresponding assay for global profiling of microRNA activity in different cell types; the other is a decoy library for suppressing microRNA activity individually or in pooled loss-of-function screens.

Gavriel Mullokandov
Alessia Baccarini
Brian D Brown
Research01 Jul 2012
Nature Methods

Volume: 9, P: 840-846
The miR-126–VEGFR2 axis controls the innate response to pathogen-associated nucleic acids

Plasmacytoid dendritic cells produce copious amounts of type I interferon in response to viral infection. Brown and colleagues show that the homeostasis and function of these cells are regulated by the microRNA miR-126.

Judith Agudo
Albert Ruzo
Brian D Brown
Research24 Nov 2013
Nature Immunology

Volume: 15, P: 54-62
Self-organization of human embryonic stem cells on micropatterns

This protocol describes how to differentiate and image human embryonic stem cells on micropatterned colonies to create radially organized domains of the germ layers mimicking embryonic gastrulation in vitro.

Alessia Deglincerti
Fred Etoc
Aryeh Warmflash
Protocols13 Oct 2016
Nature Protocols

Volume: 11, P: 2223-2232
A 3D model of a human epiblast reveals BMP4-driven symmetry breaking

Simunovic et al. use human embryonic stem cells to generate a three-dimensional model of a human pre-gastrulation epiblast and show that anterior–posterior symmetry breaking can be induced by BMP4 and WNT signalling.

Mijo Simunovic
Jakob J. Metzger
Eric D. Siggia
Research01 Jul 2019
Nature Cell Biology

Volume: 21, P: 900-910
GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions

T cells specific for GFP allow depletion of specific cell types in mice.

Judith Agudo
Albert Ruzo
Brian D Brown
Research02 Nov 2015
Nature Biotechnology

Volume: 33, P: 1287-1292

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In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles

High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries

The miR-126–VEGFR2 axis controls the innate response to pathogen-associated nucleic acids

Self-organization of human embryonic stem cells on micropatterns

A 3D model of a human epiblast reveals BMP4-driven symmetry breaking

GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions

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