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Showing 1–8 of 8 results
Advanced filters: Author: Albert S. Agustinus Clear advanced filters

  • Examining drivers of the latitudinal biodiversity gradient in a global database of local tree species richness, the authors show that co-limitation by multiple environmental and anthropogenic factors causes steeper increases in richness with latitude in tropical versus temperate and boreal zones.

    • Jingjing Liang
    • Javier G. P. Gamarra
    • Cang Hui
    Research
    Nature Ecology & Evolution
    Volume: 6, P: 1423-1437

  • Missegregated chromosomes that are sequestrated in micronuclei are subject to changes in histone modifications leading to abnormalities in chromatin accessibility that remain long after the chromosomes have been reincorporated into the primary nucleus.

    • Albert S. Agustinus
    • Duaa Al-Rawi
    • Samuel F. Bakhoum
    ResearchOpen Access
    Nature
    Volume: 619, P: 176-183

  • From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

    • Cristina Taddei
    • Bin Zhou
    • Majid Ezzati
    ResearchOpen Access
    Nature
    Volume: 582, P: 73-77

  • Proteins continuously undergo non-enzymatic modifications such as glycation, which accumulate under physiological conditions but can be enhanced in disease. Here the authors characterise histone glycation, provide evidence that it affects chromatin, particularly in breast cancer, and identify DJ-1 as a deglycase.

    • Qingfei Zheng
    • Nathaniel D. Omans
    • Yael David
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Here we investigate the role of epigenetics in the formation, transcription regulation, maintenance and termination of several non-canonical chromatin structures. Using two examples, we demonstrate how studying non-canonical structures may reveal underlying mechanisms with implications for disease and propose intriguing epigenetic avenues for further exploration.

    • Albert S. Agustinus
    • Yael David
    Comments & Opinion
    Nature Structural & Molecular Biology
    Volume: 31, P: 8-10

  • Chromosomal instability (CIN) drives cancer progression through diverse mechanisms. The authors review the molecular consequences of CIN in advanced cancer, such as genomic and phenotypic heterogeneity and cancer cell-intrinsic inflammation.

    • Xuelan Chen
    • Albert S. Agustinus
    • Samuel F. Bakhoum
    Reviews
    Nature Reviews Genetics
    Volume: 26, P: 31-46