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Showing 1–6 of 6 results

Advanced filters: Author: Albert Suades Clear advanced filters

A two-step mechanism for sugar translocation

Sugar porters are textbook examples of how transport activity is described by Michaelis–Menten kinetics. Here, using saturation transfer difference nuclear magnetic resonance spectroscopy, Ahn et al. conclude that the fully occluded state of a sugar transporter is analogous to the transition state in soluble enzymes.

Do-Hwan Ahn
Claudia Alleva
David Drew
ResearchOpen Access08 Apr 2026
Nature Structural & Molecular Biology

P: 1-12
Structural basis of specific lysine transport by Pseudomonas aeruginosa permease LysP

Pseudomonas aeruginosa survives extreme acidity by importing lysine through the LysP transporter to regulate acid-resistance genes. Here, authors reveal the cryo-EM structure of LysP and show how specific hydrogen bonds enable lysine recognition.

Deniz Bicer
Rei Matsuoka
Emmanuel Nji
ResearchOpen Access04 Dec 2025
Nature Communications

Volume: 17, P: 1-17
Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1

SLC35B1, initially thought to be a nucleotide sugar transporter, is an essential ATP/ADP exchanger that imports ATP into the endoplasmic reticulum through a unique stepwise translocation mechanism.

Ashutosh Gulati
Do-Hwan Ahn
David Drew
ResearchOpen Access21 May 2025
Nature

Volume: 643, P: 855-864
The molecular basis for sugar import in malaria parasites

Crystal structure of the Plasmodium falciparum hexose transporter PfHT1 reveals the molecular basis of its ability to transport multiple types of sugar as efficiently as the dedicated mammalian glucose and fructose transporters.

Abdul Aziz Qureshi
Albert Suades
David Drew
Research29 Jan 2020
Nature

Volume: 578, P: 321-325
Establishing mammalian GLUT kinetics and lipid composition influences in a reconstituted-liposome system

Transport assays using purified glucose transporters (GLUTs) have proven to be difficult to implement, hampering deeper mechanistic insights. Here the authors have optimized a transport assay in liposomes that will provide insight to study other membrane transport proteins.

Albert Suades
Aziz Qureshi
David Drew
ResearchOpen Access10 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris

Albert Suades
Antonio Alcaraz
Alex Perálvarez-Marín
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-11