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An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

Using ribosome profiling, Navickas et al. show that heterogeneous nuclear ribonucleoprotein C functions with PABPC4 to regulate alternative polyadenylation of a set of mRNAs, which inhibits lung metastasis in xenograft models of breast cancer.

Albertas Navickas
Hosseinali Asgharian
Hani Goodarzi
ResearchOpen Access08 May 2023
Nature Cell Biology

Volume: 25, P: 892-903
No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1

In the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1 kinase and the 5′ to 3′ exonuclease Dxo1.

Albertas Navickas
Sébastien Chamois
Lionel Benard
ResearchOpen Access08 Jan 2020
Nature Communications

Volume: 11, P: 1-11
A systematic search for RNA structural switches across the human transcriptome

SwitchSeeker combines computational and experimental techniques to identify functional RNA structural switches. Applied to the human transcriptome, it identified a novel RNA switch in the 3ʹUTR of RORC, linked to nonsense-mediated decay.

Matvei Khoroshkin
Daniel Asarnow
Hani Goodarzi
ResearchOpen Access16 Jul 2024
Nature Methods

Volume: 21, P: 1634-1645
Author Correction: Systematic identification of post-transcriptional regulatory modules

Matvei Khoroshkin
Andrey Buyan
Hani Goodarzi
Amendments and CorrectionsOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1
Systematic identification of post-transcriptional regulatory modules

RNA binding proteins (RBPs) regulate various RNA processes, yet their interactions remain poorly understood. Here, authors generate a comprehensive map of RBP interactions using multimodal data, uncovering context-specific functions and revealing complex post-transcriptional regulatory networks.

Matvei Khoroshkin
Andrey Buyan
Hani Goodarzi
ResearchOpen Access09 Sept 2024
Nature Communications

Volume: 15, P: 1-21
A Wnt twist in FTO’s role in cancer progression

FTO, an m⁶A RNA demethylase, is known mainly as an oncoprotein in various cancer types. FTO is now shown to act as a cancer suppressor in a subset of epithelial tumors through an interplay between epithelial-to-mesenchymal transition and Wnt signaling.

Albertas Navickas
Hani Goodarzi
News & Views23 Jun 2021
Nature Cancer

Volume: 2, P: 579-580
A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

Culbertson et al. profile antisense RNAs using a newly developed computational pipeline and identify NQO1-AS as contributor to breast cancer progression and lung metastasis through regulation of the redox enzyme NQO1.

Bruce Culbertson
Kristle Garcia
Hani Goodarzi
ResearchOpen Access11 May 2023
Nature Cancer

Volume: 4, P: 682-698
A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

Alex Y. Ge
Abolfazl Arab
Luke A. Gilbert
ResearchOpen Access29 Oct 2024
Scientific Reports

Volume: 14, P: 1-18
A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer

Delong Meng
Xin Zhao
Sourav Bandyopadhyay
ResearchOpen Access01 Jun 2023
Oncogene

Volume: 42, P: 2207-2217

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