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Showing 1–3 of 3 results
Advanced filters: Author: Alberto Cassetta Clear advanced filters

  • Treatment strategy of solid tumors requires continuous development. Here the authors develop a Macrophage Drug Conjugate (MDC) platform by loading ferritin-drug complexes to macrophages. MDC transfers the ferritin to cancer cells via ‘TRAnsfer of Iron binding protein’ (TRAIN) process and reduces tumor volume in various mouse tumor models.

    • Bartlomiej Taciak
    • Maciej Bialasek
    • Magdalena Krol
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-30

  • Glycogen metabolism is tightly regulated. Here the authors describe the 3D structure of the PP1/PTG protein complex, which plays a prominent role in the activation of glycogen synthesis and in the pathogenesis of Lafora disease, the most severe form of pediatric progressive epilepsy.

    • Marta Stefania Semrau
    • Gabriele Giachin
    • Graziano Lolli
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11