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Showing 1–2 of 2 results
Advanced filters: Author: Albino Bacolla Clear advanced filters

  • In this study, the authors present structures and functional analyses for the RAD51C-XRCC3 tumor suppressor complex, providing insights into recurrent mutations in cancer and Fanconi Anemia patients that uncover distinct DNA replication fork protection, restart and reversal regions.

    • Michael A. Longo
    • Sunetra Roy
    • Katharina Schlacher
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG inhibition sensitizes cells to ionizing radiation and kills cancer cells through replication fork defects.

    • Jerry H. Houl
    • Zu Ye
    • John A. Tainer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15