Phenol and cyclohexenone can interconvert by controlled palladium-catalyzed hydrogenation or oxidation, allowing N-functionalization of amines. Here this is applied to amino acids and small peptides, allowing a range of challenging substrates to be N-arylated using cyclohexenone or N-alkylated using phenol.
- Alejandra Dominguez-Huerta
- Inna Perepichka
- Chao-Jun Li
