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Inhibition of gene expression in Entamoeba histolytica with antisense peptide nucleic acid oligomers

Roberto P. Stock
Alejandro Olvera
Alejandro Alagón
Research01 Mar 2001
Nature Biotechnology

Volume: 19, P: 231-234
Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites

A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkhals snakes.

Shirin Ahmadi
Nick J. Burlet
Andreas H. Laustsen
ResearchOpen Access29 Oct 2025
Nature

Volume: 647, P: 716-725
In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

Oligoclonal mixtures of neutralising antibodies can target multiple antigen components and represent a potential therapeutic solution for the treatment of envenomation. Here, the authors generate mixtures of nanobodies against coral snake venom toxins and demonstrate they can prevent lethality of coral snake venoms in pre-clinical animal models.

Melisa Benard-Valle
Yessica Wouters
Andreas Hougaard Laustsen
ResearchOpen Access21 May 2024
Nature Communications

Volume: 15, P: 1-13
Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

Antivenoms, obtained by venom immunization, have narrow species coverage due to low immunogenicity of venom neurotoxins. Here the authors immunize horses with a designed recombinant consensus neurotoxin, and the resulting antisera protect mice from envenomation by a broad spectrum of elapid snakes.

Guillermo de la Rosa
Felipe Olvera
Gerardo Corzo
ResearchOpen Access13 Aug 2019
Nature Communications

Volume: 10, P: 1-8
Bringing antivenoms to Sub-Saharan Africa

To reduce unacceptably high death rates from snakebite envenomation, sub-Saharan Africa must adopt not only a new generation of multivalent biotech antivenoms, but also an infrastructure to deliver them.

Roberto P Stock
Achille Massougbodji
Jean-Philippe Chippaux
Comments & Opinion01 Feb 2007
Nature Biotechnology

Volume: 25, P: 173-177
Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising V_HHs discovered using a consensus antigen

Snakebite envenoming remains a critical global health issue due to the diverse antigenic profiles of snake venoms. Here, the authors develop a long-chain consensus α-neurotoxin to identify broadly neutralising heavy-chain-only antibodies, demonstrating structural mechanisms behind the broad neutralization and in vivo potential.

Anna Damsbo
Nick J. Burlet
Andreas H. Laustsen
ResearchOpen Access19 Jul 2025
Communications Chemistry

Volume: 8, P: 1-14

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Inhibition of gene expression in Entamoeba histolytica with antisense peptide nucleic acid oligomers

Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites

In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

Bringing antivenoms to Sub-Saharan Africa

Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising V_HHs discovered using a consensus antigen

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Inhibition of gene expression in Entamoeba histolytica with antisense peptide nucleic acid oligomers

Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites

In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

Bringing antivenoms to Sub-Saharan Africa

Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen

Search

Quick links

Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising V_HHs discovered using a consensus antigen