Nature Search

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

Neutrophils infiltrate glioblastomas with the capacity to engage pro/anti tumoural responses. Here the authors developed proteomic workflows to stratify neutrophil heterogeneity by function. This work provides a platform to study neutrophil proteomes with single cell resolution in glioblastoma.

Pranvera Sadiku
Alejandro J. Brenes
Sarah R. Walmsley
ResearchOpen Access15 Dec 2025
Nature Communications

Volume: 17, P: 1-17
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in long-term impairment of subsequent neutrophil effector functions.

Manuel A. Sanchez-Garcia
Pranvera Sadiku
Sarah R. Walmsley
ResearchOpen Access28 Oct 2025
Nature Immunology

Volume: 26, P: 1903-1915
Author Correction: Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

Manuel A. Sanchez-Garcia
Pranvera Sadiku
Sarah R. Walmsley
Amendments and CorrectionsOpen Access01 Dec 2025
Nature Immunology

P: 1
The Immunological Proteome Resource

Alejandro J. Brenes
Angus I. Lamond
Doreen A. Cantrell
Correspondence06 Apr 2023
Nature Immunology

Volume: 24, P: 731
Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

Cantrell and colleagues perform a comparative quantitative mass spectrometric analysis of the proteomes of naïve and activated CD4⁺ and CD8⁺ T cells. Proteomes are dynamically regulated and mTORC1 inhibition leads to differential consequences depending on cell state.

Andrew J. M. Howden
Jens L. Hukelmann
Doreen A. Cantrell
Research07 Oct 2019
Nature Immunology

Volume: 20, P: 1542-1554
The cytotoxic T cell proteome and its shaping by the kinase mTOR

Proteomic profiling can provide new insight into the cellular regulation of effector functions. Cantrell and colleagues report discordant mRNA profiles and protein profiles in activated CD8⁺ T cells and reveal new roles for mTORC1 in regulating the function of cytotoxic T lymphocytes.

Jens L Hukelmann
Karen E Anderson
Doreen A Cantrell
Research09 Nov 2015
Nature Immunology

Volume: 17, P: 104-112
Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures

Gabriel Sollberger
Alejandro J. Brenes
Andrew J. M. Howden
ResearchOpen Access12 Mar 2024
Scientific Reports

Volume: 14, P: 1-15

Search

Filter By:

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

Author Correction: Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

The Immunological Proteome Resource

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

The cytotoxic T cell proteome and its shaping by the kinase mTOR

Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures

Search

Quick links