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Showing 1–5 of 5 results
Advanced filters: Author: Aleksandra Sljukic Clear advanced filters

  • Hepatocyte organoids derived directly from human tissue enable long-term hepatocyte expansion and can be combined with portal mesenchyme and cholangiocyte organoids to form a donor-specific periportal liver assembloid system.

    • Lei Yuan
    • Sagarika Dawka
    • Meritxell Huch
    ResearchOpen Access
    Nature
    Volume: 650, P: 438-449

  • An organoid system comprising adult mouse hepatocytes, cholangiocytes and mesenchymal cells recapitulates liver morphology, biliary function and fibrotic pathology, providing a new model for studies of hepatic biology.

    • Anna M. Dowbaj
    • Aleksandra Sljukic
    • Meritxell Huch
    ResearchOpen Access
    Nature
    Volume: 644, P: 473-482

  • Organoids are cell-based in vitro models derived from stem cells, reconstituting the complex structure and function of the corresponding tissue. In this Primer, Zhao, Chen, Dowbaj, Sljukic, Bratlie, Lin et al. discuss the development of organoids and methods for controlling their cellular environment.

    • Zixuan Zhao
    • Xinyi Chen
    • Hanry Yu
    Reviews
    Nature Reviews Methods Primers
    Volume: 2, P: 1-21

  • Advances in organoid culture have enabled the modelling of many aspects of organs in vitro, transforming experimental biology. This Review provides a comprehensive overview of the current and emerging liver and pancreas organoid technologies and discusses current limitations and future directions.

    • Aleksandra Sljukic
    • Joshua Green Jenkinson
    • Meritxell Huch
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 23, P: 44-64

  • The E3 ubiquitin ligases RNF43/ZNRF3 are often mutated in cancer but their precise contribution to liver disease is unknown. Here, the authors show that RNF43/ZNRF3 alterations predispose to liver cancer by controlling the differentiation and lipid metabolic state of hepatocytes.

    • Germán Belenguer
    • Gianmarco Mastrogiovanni
    • Meritxell Huch
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19