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Regulation of age-associated B cells by IRF5 in systemic autoimmunity

A unique subset of T-bet-expressing B cells accumulates with aging and in autoimmunity. Pernis and colleagues show that dysregulation of the transcription factor IRF5 occurs after loss of the Rho GTPase–regulatory proteins DEF6 and SWAP-70 and leads to the premature generation of age-associated B cells.

Michela Manni
Sanjay Gupta
Alessandra B. Pernis
Research26 Feb 2018
Nature Immunology

Volume: 19, P: 407-419
The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity

Excessive expansion of the T follicular helper (T_FH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of T_FH cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.

Woelsung Yi
Sanjay Gupta
Alessandra B. Pernis
ResearchOpen Access15 Aug 2017
Nature Communications

Volume: 8, P: 1-14
Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF) restrained pathogenic process involving TLR7.

Edd Ricker
Michela Manni
Alessandra B. Pernis
ResearchOpen Access10 Aug 2021
Nature Communications

Volume: 12, P: 1-21
‘-Omics’ shed light on B cells in lupus

Epigenetic and transcriptional analyses of B cell subsets from patients with systemic lupus erythematosus reveal extensive effects of the disease environment and identify previously unknown connections and regulators of DN2 B cells and ABC-like cells.

Alessandra B. Pernis
Lionel B. Ivashkiv
News & Views08 Jul 2019
Nature Immunology

Volume: 20, P: 946-948
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

The authors identify in patients with rheumatoid arthritis a pathogenic subset of CD4+ T cells that augments B cell responses within inflamed tissues.

Deepak A. Rao
Michael F. Gurish
Michael B. Brenner
Research02 Feb 2017
Nature

Volume: 542, P: 110-114
Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

Nirmal K. Banda
Larry W. Moreland
V. Michael Holers
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-18
Selective dysregulation of ROCK2 activity promotes aberrant transcriptional networks in ABC diffuse large B-cell lymphoma

Edd Ricker
Akanksha Verma
Alessandra B. Pernis
ResearchOpen Access04 Aug 2020
Scientific Reports

Volume: 10, P: 1-17
Association of circulating gene expression signatures with stiffness following total knee arthroplasty for osteoarthritis: a pilot study

Meghan A. Kirksey
Samantha G. Lessard
Miguel Otero
ResearchOpen Access25 Jul 2022
Scientific Reports

Volume: 12, P: 1-12

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