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Showing 1–8 of 8 results
Advanced filters: Author: Alessandra Dall’Agnese Clear advanced filters

  • Induction of mitochondrial oxidative respiration is required for stem cell differentiation, but the mechanisms underlying this process are poorly understood. Here, the authors report that Stat3 promotes muscle stem cell differentiation by stimulating mitochondrial respiration via Fam3a.

    • David Sala
    • Thomas J. Cunningham
    • Alessandra Sacco
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate cancer contributing to intratumor heterogeneity in clinical samples.

    • Paloma Cejas
    • Yingtian Xie
    • Henry W. Long
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Animal studies have shown that the nutritional status of parents can predispose the offspring to obesity and obesity-related diseases. Here the authors show that cardiac dysfunction induced by a high-fat diet persists for two generations in Drosophila, and that targeted expression of ATGL/bmm in the offspring, as well as inhibition of H3K27 trimethylation, is cardioprotective.

    • Maria Clara Guida
    • Ryan Tyge Birse
    • Rolf Bodmer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The chromatin protein MeCP2 is a component of dynamic, liquid-like heterochromatin condensates, and the ability of MeCP2 to form condensates is disrupted by mutations in the MECP2 gene that occur in the neurodevelopmental disorder Rett syndrome.

    • Charles H. Li
    • Eliot L. Coffey
    • Richard A. Young
    Research
    Nature
    Volume: 586, P: 440-444

  • In skeletal muscle progenitors, EZH2 maintains myogenic genes in a repressed state, but during differentiation its levels are reduced via unknown mechanisms. Here the authors show that during myogenesis, p38α kinase phosphorylates EZH2 and targets it for degradation by the ubiquitin ligase PRAJA1.

    • Silvia Consalvi
    • Arianna Brancaccio
    • Daniela Palacios
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • RNA polymerase II with a hypophosphorylated C-terminal domain preferentially incorporates into mediator condensates, and with a hyperphosphorylated C-terminal domain into splicing-factor condensates, revealing phosphorylation as a regulatory mechanism in condensate preference.

    • Yang Eric Guo
    • John C. Manteiga
    • Richard A. Young
    Research
    Nature
    Volume: 572, P: 543-548