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Natural killer cells and dendritic cells: rendezvous in abused tissues

Alessandro Moretta
Reviews01 Dec 2002
Nature Reviews Immunology

Volume: 2, P: 957-965
Aegean reflections on innate immunity

George Hajishengallis
Alberto Mantovani
John D Lambris
News & Views18 Sept 2013
Nature Immunology

Volume: 14, P: 1025-1029
What is a natural killer cell?

Natural killer cells have been arbitrarily defined using a number of different phenotypic and functional criteria. We asked Lorenzo Moretta if we have truly discovered the core identity of this critical player in eliciting immune responses.

Alessandro Moretta
Cristina Bottino
Lorenzo Moretta
Comments & Opinion01 Jan 2002
Nature Immunology

Volume: 3, P: 6-8
Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma

Guillaume Dorothée
Hamid Echchakir
Fathia Mami-Chouaib
Research16 Oct 2003
Oncogene

Volume: 22, P: 7192-7198
PD-1 is expressed by and regulates human group 3 innate lymphoid cells in human decidua

Paola Vacca
Silvia Pesce
Emanuela Marcenaro
Research12 Feb 2019
Mucosal Immunology

Volume: 12, P: 624-631
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors

Gastrointestinal stromal tumors can respond to imatinib mesylate therapy owing to its inhibitory action on tumor cells as well as off-target effects on NK cells. This report shows that a different frequency of genetically determined expression profiles of isoforms of the NK cell receptor NKp30, which show various functional properties, is associated with GIST and influences survival after imatinib treatment.

Nicolas F Delahaye
Sylvie Rusakiewicz
Laurence Zitvogel
Research08 May 2011
Nature Medicine

Volume: 17, P: 700-707
Enrichment of CD56^dimKIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients

The role of NK cells in tumour lymphatics is poorly understood. Here, the authors show that the tumour cell-infiltrated lymph nodes of melanoma patients have an altered cytokine milieu and contain an expanded population of NK cells with high tumour-cytotoxic activity.

Talib Hassan Ali
Simona Pisanti
Ennio Carbone
Research04 Dec 2014
Nature Communications

Volume: 5, P: 1-9
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors

Oncolytic virotherapy has been tested in cancer patients, but its efficacy is uncertain. Alvarez-Breckenridge et al. now report that in mouse models of glioblastoma, an antiviral response mediated by natural killer (NK) cells may impair the anticancer efficacy of oncolytic virotherapy. Their findings suggest that limiting the cytolytic activity of NK cells might enhance replication of oncolytic viruses and increase tumor cell killing.

Christopher A Alvarez-Breckenridge
Jianhua Yu
E Antonio Chiocca
Research25 Nov 2012
Nature Medicine

Volume: 18, P: 1827-1834
Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores

Kinetochores assemble on centromeres via histone H3 variant CENP-A and low levels of centromere transcripts (cenRNAs). Here the authors show the Rio1 kinase limits cenRNA production by reducing RNAPII accessibility and promotes cenRNA degradation by the 5’− 3’exoribonuclease Rat1.

Ksenia Smurova
Michela Damizia
Peter De Wulf
ResearchOpen Access01 Jun 2023
Nature Communications

Volume: 14, P: 1-19
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour growth.

Sara Trabanelli
Mathieu F. Chevalier
Camilla Jandus
ResearchOpen Access19 Sept 2017
Nature Communications

Volume: 8, P: 1-14
NK cells in HIV infection: Paradigm for protection or targets for ambush

Anthony S. Fauci
Domenico Mavilio
Shyam Kottilil
Reviews20 Oct 2005
Nature Reviews Immunology

Volume: 5, P: 835-843
A bioinformatic study of antimicrobial peptides identified in the Black Soldier Fly (BSF) Hermetia illucens (Diptera: Stratiomyidae)

Antonio Moretta
Rosanna Salvia
Patrizia Falabella
ResearchOpen Access09 Oct 2020
Scientific Reports

Volume: 10, P: 1-14
The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1

Ashwin Narayanan
Filippo Gagliardi
Rossella Galli
ResearchOpen Access11 Dec 2018
Cell Death & Differentiation

Volume: 26, P: 1813-1831

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Natural killer cells and dendritic cells: rendezvous in abused tissues

Aegean reflections on innate immunity

What is a natural killer cell?

Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma

PD-1 is expressed by and regulates human group 3 innate lymphoid cells in human decidua

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors

Enrichment of CD56^dimKIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients

NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors

Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

NK cells in HIV infection: Paradigm for protection or targets for ambush

A bioinformatic study of antimicrobial peptides identified in the Black Soldier Fly (BSF) Hermetia illucens (Diptera: Stratiomyidae)

The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1

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