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Showing 1–4 of 4 results
Advanced filters: Author: Alessandro Verrecchia Clear advanced filters

  • DNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression.

    • Fabio Iannelli
    • Alessandro Galbiati
    • Fabrizio d’Adda di Fagagna
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Global transcriptional and epigenomic analyses in diverse cell types reveal that the primary action of Myc is to up- and downregulate transcription of distinct groups of genes, rather than to amplify transcription of all active genes; general RNA amplification, when observed, is better explained as an indirect consequence of Myc’s action on cellular physiology.

    • Arianna Sabò
    • Theresia R. Kress
    • Bruno Amati
    Research
    Nature
    Volume: 511, P: 488-492

  • The acetyl-transferase Tip60 regulates transcription and is involved in the DNA damage response. Now, work from a mouse model and in-human tumours provides evidence that Tip60 is a tumour suppressor gene, and suggests that Tip60 functions in an oncogene-induced DNA damage response that restrains early tumourigenesis.

    • Chiara Gorrini
    • Massimo Squatrito
    • Bruno Amati
    Research
    Nature
    Volume: 448, P: 1063-1067

  • Cyclin-dependent kinase 2 (cdk2) is surprisingly found to suppress senescence induced by the Myc oncogene in various cell types. Inactivation or deletion of cdk2 sensitizes mouse embryonic fibroblasts to Myc-induced senescence via a mechanism requiring pRb and p53.

    • Stefano Campaner
    • Mirko Doni
    • Bruno Amati
    Research
    Nature Cell Biology
    Volume: 12, P: 54-59