Through genetic mouse models, pharmacological interventions and in vitro assays, Beck et al. show that thrombin-mediated platelet glycoprotein V (GPV) shedding does not affect platelet activation but prevents excessive thrombin-mediated fibrin deposition and thereby controls hemostasis, thrombosis and thrombo-inflammation. The GPV-mediated spatio-temporal control of fibrin formation on thrombogenic surfaces could be targeted to restrict thrombosis while preserving hemostasis.
- Sarah Beck
- Patricia Öftering
- Bernhard Nieswandt
