Xenotransplantation is a promising option when allogeneic donors are unavailable but hampered by a more stringent immunological barrier. Here authors show that hypoimmune cells engineered to overcome xenogeneic cytotoxicity of polymorphonuclear cells in addition to averting responses by other immune cell types might improve pig-to-human xenotransplantation.
- Xiaomeng Hu
- Grigol Tediashvili
- Sonja Schrepfer
