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Showing 1–4 of 4 results
Advanced filters: Author: Alessia Grozio Clear advanced filters

  • Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD+, but how NMN is taken up into cells has not been entirely clear. Here the authors discover a specific NMN transporter, encoded by the Slc12a8 gene, which regulates NMN uptake and cellular NAD+ levels in vitro and in the mouse intestine in vivo.

    • Alessia Grozio
    • Kathryn F. Mills
    • Shin-ichiro Imai
    Research
    Nature Metabolism
    Volume: 1, P: 47-57

  • Nicotinamide adenine dinucleotide (NAD+) is a central redox factor and enzymatic cofactor that functions in a plethora of cellular processes, including metabolic pathways and DNA metabolism, and affects cell fate and function. NAD+ levels gradually decline with age, and therapeutic elevation of NAD+ levels is being trialled for extending human healthspan and lifespan.

    • Anthony J. Covarrubias
    • Rosalba Perrone
    • Eric Verdin
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 22, P: 119-141