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Showing 1–8 of 8 results
Advanced filters: Author: Alessia Perino Clear advanced filters

  • Perino and Schoonjans summarize the most recent literature on the receptor-mediated role of bile acid signalling in the control of peripheral and central energy homeostasis.

    • Alessia Perino
    • Kristina Schoonjans
    Reviews
    Nature Metabolism
    Volume: 4, P: 416-423

  • The kinase PI3K is crucial for insulin signalling in the liver but the roles of individual PI3K isoforms are largely unclear. Using mice that lack class II PI3K isoform γ (PI3K-C2γ), the authors here show that PI3K-C2γ selectively activates endosomal Akt2 by regulating the localized production of PIP2.

    • Laura Braccini
    • Elisa Ciraolo
    • Emilio Hirsch
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15

  • White adipose tissue can undergo a process of beiging and acquire functional characteristics similar to brown adipose tissue, including the ability to dissipate energy via uncoupled respiration. Here, Velazquez-Villegas et al. show that activation of the bile acid membrane receptor, TGR5, leads to white adipocyte beiging by promoting mitochondrial fission.

    • Laura A. Velazquez-Villegas
    • Alessia Perino
    • Kristina Schoonjans
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Bile acids exert metabolic effects by modulating FXR receptor activity. Here, Trabelsi et al.show that FXR negatively regulates production of the incretin GLP-1 in enteroendocrine L-cells by reducing glycolysis and that inhibition of FXR improves glucose metabolism by increasing GLP-1 in obese mice.

    • Mohamed-Sami Trabelsi
    • Mehdi Daoudi
    • Sophie Lestavel
    Research
    Nature Communications
    Volume: 6, P: 1-13

  • Enormous differences exist between human studies, which show a strong association of low vitamin D status with obesity, and mouse data, where low vitamin D signalling causes resistance to obesity. Understanding these discrepancies may provide better insight into the spectrum of activities of vitamin D and should be of interest considering the world epidemic of obesity and the metabolic syndrome.

    • Roger Bouillon
    • Geert Carmeliet
    • Annemieke Verstuyf
    Reviews
    Nature Reviews Endocrinology
    Volume: 10, P: 79-87

  • Bile acids are shown to enter the brain and regulate short-term reductions in food intake after a meal by inhibiting neuropeptide release from agouti-related peptide/neuropeptide Y neurons.

    • Alessia Perino
    • Laura. A. Velázquez-Villegas
    • Kristina Schoonjans
    Research
    Nature Metabolism
    Volume: 3, P: 595-603