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Showing 1–4 of 4 results
Advanced filters: Author: Alessia Zamborlini Clear advanced filters

  • SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. describe an additional SUMOylation at residue K595, which promotes the dNTPase-independent restriction activity.

    • Charlotte Martinat
    • Arthur Cormier
    • Alessia Zamborlini
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Next-generation sequencing has facilitated the study of how transposable elements and retroviruses select their diverse genomic sites of integration, and revealed integration site preferences that range from specific nucleotide sequences to particular chromatin states. The authors review the various mechanisms of integration site selection in eukaryotes, as well as the molecular and cellular determinants that guide this process.

    • Tania Sultana
    • Alessia Zamborlini
    • Pascale Lesage
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 292-308

  • Protein modification by small ubiquitin-related modifier (SUMO) proteins is associated with antiviral responses. Here, the authors show that interferons increase the level of expression of SUMO proteins via a let-7 microRNA-controlled mechanism, and this contributes to the antiviral effects of interferons.

    • Umut Sahin
    • Omar Ferhi
    • Valérie Lallemand-Breitenbach
    Research
    Nature Communications
    Volume: 5, P: 1-8