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Advanced filters: Author: Alessio Ottaviani Clear advanced filters
  • B cell malignancies resistant to conventional treatments are potentially sensitive to CAR-T cell immune therapy, but its clinical applicability is limited by immune related adverse effects. Here authors show in a humanized mouse model that blocking IFNγ with the monoclonal antibody emapalumab mitigates the adverse effects of CAR.CD19-T cells without compromising their anti-lymphoma efficacy.

    • Simona Manni
    • Francesca Del Bufalo
    • Concetta Quintarelli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13