Nature Search

Crosstalk between TGF-β and Wnt/β-catenin signaling drives fibrogenic and stem-like phenotypes in senescent MDA-MB-231 breast cancer cells

Mona El Samarji
Elissa Alam
Mohamad Rima
ResearchOpen Access03 Jan 2026
npj Aging

P: 1-17
Illuminating protein space with a programmable generative model

Evolution has produced a range of diverse proteins, and now a generative model called Chroma can expand that set by allowing the user to design new proteins and protein complexes with desired properties and functions.

John B. Ingraham
Max Baranov
Gevorg Grigoryan
ResearchOpen Access15 Nov 2023
Nature

Volume: 623, P: 1070-1078
Publisher Correction: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

Sang Ho Park
Alex Ayoub
Uhn-Soo Cho
Amendments and CorrectionsOpen Access27 Feb 2020
Nature Communications

Volume: 11, P: 1
Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin

Regulation of the MLL family of histone H3K4 methyltransferases on the nucleosome core particle (NCP) remains largely unknown. Here the authors show that intrinsically disordered regions of ASH2L and DPY30 restrict the rotational dynamics of MLL1 on the NCP, allowing more efficient enzyme-substrate engagement and higher H3K4 trimethylation activity.

Young-Tae Lee
Alex Ayoub
Yali Dou
ResearchOpen Access19 May 2021
Nature Communications

Volume: 12, P: 1-13
Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

MLL family histone methyltransferases deposit histone H3 Lys4 mono-/di-/tri-methylation and regulate gene expression in mammals. Here the authors report the single-particle cryo-EM structure of the NCP-bound human MLL1 core complex, shedding light on how the MLL1 complex engages chromatin and how chromatin binding promotes MLL1 tri-methylation activity.

Sang Ho Park
Alex Ayoub
Uhn-Soo Cho
ResearchOpen Access05 Dec 2019
Nature Communications

Volume: 10, P: 1-13
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Aberrant neurophysiological signaling associated with speech impairments in Parkinson’s disease

Alex I. Wiesman
Peter W. Donhauser
Sylvia Villeneuve
ResearchOpen Access14 Apr 2023
npj Parkinson's Disease

Volume: 9, P: 1-13

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